Understanding the Role of Adalimumab in the Treatment of Moderately to Severely Active Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory colonic disease with repetitive episodes of remission and relapse. Although the precise etiology of UC remains unclear, interactions between the immune system and the environment and, in particular, interactions between the genetic make-up and gut microbiota are considered to be the main factors responsible for UC development. Recently, the therapeutic options for UC have increased, and several biologic agents, including anti-tumor necrosis factor (anti-TNF) agents (infliximab, certolizumab pegol, adalimumab, and golimumab) and anti-integrin molecules (natalizumab and vedolizumab), are now available in clinical practice. These biologic agents could be an optimal choice for the treatment of patients with moderately to severely active UC who have not been successfully treated with conventional therapies consisting of steroids and/or immunomodulators. In the absence of headto-head trials, recently, two network meta-analyses have been conducted to compare the efficacy of various biologic agents in the treatment of moderately to severely active UC. Danese et al. showed that biologic agents (adalimumab, golimumab, infliximab, and vedolizumab) were superior to a placebo in terms of induction or maintenance of clinical remission and suggested that infliximab is more likely to induce a favorable clinical outcome than adalimumab. Stidham et al. demonstrated that biologic agents (infliximab, adalimumab, and golimumab) are effective in the induction and maintenance of remission of UC and showed that no single agent is clinically superior to any other. Adalimumab is a fully human IgG1 monoclonal antibody against TNF-α. Phase III trials in patients with moderately to severely active UC have demonstrated the safety and efficacy of adalimumab in inducing and maintaining clinical remission at an induction dose of 160/80 mg (week 0/week 2) and a maintenance dose of 40 mg every other week. Colombel et al. showed that long-term treatment with adalimumab for up to 4 years is well tolerated and is beneficial for patients with moderately to severely active UC. Based on these results, adalimumab has been approved worldwide for the treatment of adult patients with moderately to severely active UC. When deciding upon a biologic agent, several parameters including patient preference, potential for immunogenicity, and cost-effectiveness as well as comparative efficacy and safety should be considered. Because adalimumab is administered subcutaneously and requires a short time for therapy, which consists of a single injection, this agent can be used conveniently and easily at home. A prospective survey to assess the preferences of patients for selecting anti-TNF agents revealed that the majority of patients preferred agents that were administered by subcutaneous injection rather than by intravenous infusion. Associations between immunogenic events (such as infusion reactions and loss of response) and antibodies to infliximab or adalimumab have been demonstrated. According to data from Ben-Horin et al., antiadalimumab antibodies do not cross-react with infliximab, and switching between infliximab and adalimumab is often advocated when the response to one drug is lost. Cost issues might also guide treatment choice. However, data on the cost-effectiveness of biologic agents are still lacking. Recently, Zhang et al. reported a meta-analysis of the efficacy and safety of adalimumab for patients with moderately to severely active UC who are unresponsive to conventional therapies. In that study, three randomized controlled trials were included to compare the efficacy and safety of adalimumab to a placebo. The authors revealed that adalimumab was more effec-